nanoBioSciences, LLC has developed the patented Advanced micro-needle array (AdminPatch®) which is superior to other various microneedle technologies.

The AdminPatch array painlessly and instantaneously forms hundreds of tiny aqueous channels (‘micropores’) through the stratum corneum and epidermis, the outer resistive surface layers of the skin. Numerous drugs including proteins and water-soluble molecules can enter the body through these aqueous micropores for either local effect, or by entering the circulation, for systemic effect. The created aqueous channels stay constantly open while AdminPatch array is applied on the skin and, therefore, enable the rapid, sustained, and efficient delivery of drugs through these aqueous channels formed in the skin surface. When the microneedle array is removed from the skin, the micropores simply collapse and the skin barrier is quickly restored.

The microneedles are formed from a standard stainless-steel film which allows very robust and inexpensive high-volume manufacturing of the microneedle arrays. A simple low-cost molded plastic part is simply attached on the back surface of the AdminPatch microneedle array to provide a fluidic connection to an externally connected liquid drug reservoir. AdminPatch microneedle based device is fully compatible with all currently produced reusable and disposable pre-filled pens and standard pre-filled glass drug cartridges.

AdminPatch™ Microneedle Array

Additionally, to create an advanced transdermal patch, a conventional transdermal drug-in-adhesive patch can be simply laminated on the back surface of the AdminPatch microneedle array. The AdminPatch microneedle arrays can be also elastically stretched and deformed to better conform to contoured and flexible skin surface. The flexibility of the microneedle array is provided by a substrate design having a network of interconnected spring elements.

The Company expects that the AdminPatch microneedle based devices will have attractive profit margins since both the microneedle array and the injection-molded support / syringe connector can be manufactured at low cost using mature, large-scale processes. The AdminPatch microneedle based device do not use any electronic components and can be entirely outsourced to low-cost precision stamping and plastic molding vendors.

Please feel free to contact us for more information.